Transparent to the transcendent. Wrote a book on Long Covid. - https://jondouglas.dev/longhaul/ Extraordinary claims require extraordinary evidence. - Sagan
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Bengbu China 6 healthy men took a single oral dose of [14C] RAY1216 a SARS-CoV-2 Mpro inhibitor. The drug was rapidly absorbed peaked in 1.5h and was mostly excreted in feces with over 90 percent cleared in 96h. Safety was favorable. journals.sagepub.com/doi/10.1177/...
Seville Spain 671 mother–child pairs were followed for a year. Researchers found that prenatal COVID-19 exposure or maternal stress was not linked to developmental delays at 6 or 12 months though severe maternal COVID hinted at more social concerns. link.springer.com/article/10.1...
Sakarya University studied 20 COVID-19 patients and found that early changes in white blood cells, platelets, and liver enzymes were significant, but CD4 and CD8 T cell counts and cytokine levels stayed stable. www.researchsquare.com/article/rs-7...
France Rhône-Alpes, 362 nurses surveyed. Nearly 40% cared for Long COVID patients, often without training. Nurses stepped into roles from psychological support to screening, with 80% ready to coordinate patient care. www.researchsquare.com/article/rs-7...
Belo Horizonte and Ribeirão Preto hospitals studied 30 ICU COVID-19 patients and 30 healthy controls. Those who died showed early IgM anti-N and anti-RBD antibodies plus cytokine storm, while survivors had steadier IL-13, hinting at protection. www.researchsquare.com/article/rs-7...
Former US Surgeon General Jerome Adams says he’s getting the updated COVID shot this year. Vaccines still prevent hospitalizations, reduce long COVID risk, and protect loved ones. Most adults have risk factors whether they realize it or not. www.medpagetoday.com/opinion/seco...
Ann Arbor and New Haven researchers reviewed 429 studies with over 2 million people and found long COVID affects 36% worldwide, lasting up to 2 years, with fatigue, respiratory and neurological issues most common, and higher risk if unvaccinated. academic.oup.com/ofid/advance...
Researchers studying mice and human tumors found that T cells don’t just age by shortening telomeres. Instead, oxidative stress damages telomeres directly, pushing T cells into dysfunction. Shielding telomeres preserved their cancer-fighting power. www.cell.com/immunity/ful...
Seoul National University with collaborators in France, India, UAE, Australia, and NIH identified ZAP-180013, a new NLRP3 inhibitor that blocks inflammasome assembly, overcomes MCC950 resistance, and reduces inflammation in mice. www.cell.com/cell-chemica...
Vienna researchers reveal that a special neutrophil subset clogs tumor vessels with extracellular traps, sparking necrosis that drives cancer cells to spread. Blocking these traps cut metastasis without shrinking tumors. www.cell.com/immunity/ful...
Kerbala, Iraq. In 161 patients followed 6–9 months after COVID, those with lower oxygen and higher fever during infection showed greater NLRP3 inflammasome activity, linked to fatigue, anxiety, and depression in Long COVID. www.medrxiv.org/content/10.1...
Austria and Liechtenstein researchers reviewed 44 studies with 7571 people. They found that autoantibodies, especially against cell nuclei and GPCRs, are often linked to long COVID and may become useful diagnostic markers. www.thelancet.com/journals/lan...
Halifax and Calgary researchers show that coronavirus M proteins disrupt the Golgi’s structure and block host protein trafficking while still allowing new viruses to exit, revealing a stealth strategy to weaken immune defenses. www.biorxiv.org/content/10.1...
Vancouver and Toronto scientists screened 25 million molecules with AI to target SARS-CoV-2 Mac1. They found a new neutral inhibitor confirmed by crystallography and expanded it into a promising chemical series. www.biorxiv.org/content/10.1...
Parma researchers showed that cytokines from SARS-CoV-2 spike activated macrophages trigger endothelial cells to shift toward fibrosis but the drugs infliximab and baricitinib together can block and even reverse this harmful transition. www.mdpi.com/1422-0067/26...
Barcelona 59 long covid patients with chest pain were studied by stress cardiac MRI. 39 percent showed microvascular dysfunction and 8.5 percent had signs of prior myocarditis but none had heart attack or pericardial disease. www.sciencedirect.com/science/arti...
Portugal, 208 patients with long COVID were followed. Fatigue was strongly tied to anxiety and depression. Surprisingly, those with mild or moderate initial illness reported more fatigue and worse quality of life than severe cases. journals.lww.com/md-journal/f...
US study of 21,631 adults finds those facing food insecurity had a 78% higher chance of long COVID and 34% lower chance of recovery. SNAP benefits and employment eased these risks, suggesting food aid may reduce long COVID’s burden. jamanetwork.com/journals/jam...
US study of 500 hospitalized COVID patients found a multi-omics recovery factor that predicted long COVID from admission. Lower scores linked to inflammation, anemia pathways, and reduced androgens, pointing to early biomarkers and targets. www.jci.org/articles/vie...
In the UK, researchers tested a targeted PD-1 agonist that binds to pancreatic beta cells and found it powerfully inhibits PD-1+ NK cells, reducing inflammation and protecting insulin-producing cells This may offer new hope for treating type 1 diabetes www.frontiersin.org/journals/imm...
NIH/FDA researchers analyzed 21 children and found that SARS-CoV-2 infection triggered more mucosal memory B cells with IgA and CXCR3 markers than vaccination, suggesting infection may lead to stronger, more localized upper airway immunity. www.researchsquare.com/article/rs-7...
Harare researchers reviewed 15 studies and found that neutrophil-related biomarkers like MPO, NETs, IL-6, and D-dimer consistently rise in severe COVID-19 and predict worse outcomes, suggesting promising targets for early diagnosis and treatment. www.researchsquare.com/article/rs-7...
Nanchang University researchers analyzed 79 patients and found that the SARS-CoV-2 spike protein drives lung fibrosis by boosting IL-33, which triggers EMT through β-catenin activation and PPAR-γ suppression. IL-33 may be a key treatment target. www.researchsquare.com/article/rs-7...
In a trial of 1049 adults with severe COVID-19 across the US, researchers found that abatacept plus standard care may reduce 28-day mortality and improve recovery when baricitinib or tocilizumab are unavailable. Evidence remains low certainty. academic.oup.com/cid/advance-...
Boston researchers studied humanized mice with lung tissue and found that SARS-CoV-2 clears when CD4+ monocytes, not T-cells, drive the response. These monocytes act as key antiviral sentinels, preventing infection from persisting. journals.plos.org/plospathogen...
New Haven study of 32 women finds that neuropsychiatric long COVID leaves a unique genetic imprint in cerebrospinal fluid, activating stress and metabolism pathways not seen in blood, pointing to brain-specific immune disruption. academic.oup.com/jid/advance-...
It is and I believe this was used heavily during polio and HIV days too.
601 adults primed with non mRNA vaccines were followed for 24 months after receiving either a half or full dose Pfizer booster Both doses gave equally durable protection with no hospitalisations supporting fractional dosing as safe and cost saving www.medrxiv.org/content/10.1...
Duhok Iraq 535 viral genomes show Delta entered three months before a travel ban and Omicron spread despite restrictions Both quickly seeded community transmission Travel bans were too late while genomic surveillance proved far more effective www.medrxiv.org/content/10.1...
Denmark studied 471,272 adolescents aged 12–15. The Pfizer vaccine cut moderate COVID infections by 54% soon after two doses but protection fell to 23% within 11 months. Severe cases were rare yet protection remained stronger. www.sciencedirect.com/science/arti...
Helsinki researchers followed 120 COVID-19 patients and found that B cell and T helper cell changes during infection returned to normal within 200 days. Even herpesvirus reactivations in severe cases were not linked to lasting immune problems. www.sciencedirect.com/science/arti...
Suzhou researchers highlight that nearly 1 in 3 people may face long COVID yet doctors often miss it due to vague definitions and lack of biomarkers. They call for unified criteria, education, and patient-centered care. www.frontiersin.org/journals/med...
Twelve US children’s hospitals studied 10,618 patients and 48,287 clinical notes. Nearly all 25 tracked symptoms were more common in kids with long COVID, with pain and digestive issues most frequent. NLP revealed what billing codes missed. academic.oup.com/jamiaopen/ar...
United States study of 42,000 older adults with COVID found those with dementia were more likely to die in hospital, need long term care, stay longer, cost more, and face complications like delirium and organ failure onlinelibrary.wiley.com/doi/10.1111/...
Mice and monkeys given the flu vaccine with a new NLRP3-stimulatory adjuvant made stronger T cell and antibody responses than with standard adjuvants. Researchers say this could be a step toward a universal flu vaccine. journals.asm.org/doi/10.1128/...
Imagine if your own T-cells could be taught to sweep out the viral ghosts of COVID still haunting your body. That’s TechImmune’s moonshot. And the team behind it? Absolutely stacked. techimmune.com/about-us/
Atlanta scientists engineered a hexameric coiled coil to display DARPin proteins, creating HEX-DARPins that potently neutralize multiple SARS-CoV-2 variants and last longer in the bloodstream of mice. pubs.acs.org/doi/10.1021/...
Clemson scientists found disinfectant wipes cut coronavirus surrogates by over 99.9% on glass and vinyl in 1 minute, equally effective by hand or machine. journals.asm.org/doi/10.1128/...
Barcelona hospital study of 108 immunocompromised patients finds subgenomic RNA testing best identifies who still carries viable SARS-CoV-2, outperforming standard PCR and culture for guiding isolation and treatment. journals.asm.org/doi/10.1128/...
Madrid researchers tested 120 positive swabs and found SARS-CoV-2 RNA can persist for months. RT-PCR results and Ct values fluctuated, showing why clinical decisions should not rely on repeated PCR tests alone. journals.asm.org/doi/10.1128/...
Ankara University researchers created PEG-PCL nanoparticles carrying the SARS-CoV-2 spike RBD. They stayed under 300 nm, kept the antigen intact, released it steadily, and activated immune cells, showing promise for safer subunit vaccines. onlinelibrary.wiley.com/doi/10.1002/...
Australia and UK 1,046 parents tracked before and during COVID. Parents with pre-pandemic mental health struggles used less emotion coaching, and dismissing children's feelings predicted more behavior problems later. link.springer.com/article/10.1...
Zhongshan People’s Hospital studied 142 ICU patients with COVID-19. Over half developed acute kidney injury and those with AKI faced nearly 4 times higher risk of death even after adjusting for other factors. www.researchsquare.com/article/rs-7...
MIT researchers show the airway brain axis links breathing to cough, inflammation, and even emotion, offering new paths to treat asthma, chronic cough, and long COVID. www.cell.com/cell-reports...
Switzerland 5657 adults tracked over 2.5 years showed that pandemic worries, financial risk, and stress symptoms were tied to lasting negative emotions, while stronger neighbor ties and active lifestyles briefly eased the strain. academic.oup.com/jpubhealth/a...
Mexico study of 70 non-diabetic COVID-19 patients found that a fibrinogen-to-platelet ratio above 34.2 on admission doubled the risk of death, outperforming other common blood biomarkers of mortality. www.tandfonline.com/doi/full/10....
India 5 COVID-19 brain autopsies and human neuron cultures reveal that SARS-CoV-2 Orf6 hijacks the mitochondrial protein MTCH1, causing oxidative stress and necroptosis, a pathway that may underlie long COVID brain fog. www.researchsquare.com/article/rs-7...
Across 16 countries, researchers studied over 2000 people and found that COVID-19 survivors had stiffer arteries than controls. Even mild cases aged women’s arteries by about 5 years, raising long-term heart risks. www.nature.com/articles/s43...
Xiamen researchers studied 35 patients with Sjögren’s disease and 25 healthy people and found that a virus called Vientovirus mimics the body’s own proteins, triggering autoantibodies that may drive the disease. www.nature.com/articles/s41...
Xiamen researchers studied 35 patients with Sjögren’s disease and 25 healthy people and found that a virus called Vientovirus mimics the body’s own proteins, triggering autoantibodies that may drive the disease. www.nature.com/articles/s41...
The amount of references of “it is the Long COVID of X” is staggering. Has anyone compiled all these references? The long COVID of American politics, of the economy, of the workplace, of tech layoffs, etc
Researchers redesigned tilorone into new 9-fluorenone sulfonamides. Two compounds, 3e and 3h, inhibited SARS-CoV-2 main protease (Mpro) and papain-like protease (PLpro) and suppressed viral replication in cells with low toxicity. link.springer.com/article/10.1...
Philadelphia study of 38 preterm and 10 term infants found that severe lung disease drove a Th17-skewed immune state, while systemic infections triggered lasting oligoclonal T cell responses. Different early complications imprint distinct immune paths. www.medrxiv.org/content/10.1...
UC Davis researchers introduce CELLECTION, a deep learning tool that predicts complex traits directly from single-cell data. It outperforms existing methods and uncovers disease-driving cell states in long COVID, lupus, cardiomyopathy, and Alzheimer’s. www.biorxiv.org/content/10.1...
Brazil 60 young adults were studied and those with long COVID showed poorer memory and executive function along with higher inflammation. Carriers of the Val allele in the SOD2 gene had stronger inflammatory responses, hinting at genetic risk. www.sciencedirect.com/science/arti...
Rwanda surveyed 3,143 adults and found that 34% still face long COVID nearly three years later. Back pain, fatigue, headaches, and brain fog were common. Women, older adults, repeat infections, and anxiety carried the greatest risk. www.sciencedirect.com/science/arti...
Netherlands study of 95 long COVID patients found that higher personal exposure to fine particulate air pollution (PM2.5) tripled the risk of persistent airway abnormalities on CT scans up to 15 months after infection. www.sciencedirect.com/science/arti...
United States 523,755 people with COVID were tracked in 2022–2023. Nearly half of adults and one third to almost half of children developed long COVID within a year, with risk highest in older, sicker patients. www.sciencedirect.com/science/arti...
In Italy a 79 year old woman developed sudden alopecia universalis one month after COVID-19. Steroids failed, systemic therapy restored hair growth, but relapse came after stopping. The case shows post-COVID AU may be rapid and relapsing. pubmed.ncbi.nlm.nih.gov/40911746/
Ontario study tested 32 vials of Pfizer and Moderna COVID-19 vaccines and found billions of plasmid DNA fragments per dose. Pfizer vials contained SV40 promoter-enhancer DNA, with some exceeding FDA safety limits, while Moderna stayed within limits. www.tandfonline.com/doi/full/10....
London researchers argue Epstein-Barr virus is not just linked to multiple sclerosis but may drive it by cycling between latent and lytic states. They call for antivirals and immunotherapies that directly target EBV as new MS treatments. academic.oup.com/brain/articl...
China Phase 2 trial with 272 adults found that a single IV dose of AZD7442, a combination of tixagevimab and cilgavimab, was safe, well tolerated, boosted neutralizing antibodies, and showed no meaningful race effect on drug behavior. accp1.onlinelibrary.wiley.com/doi/10.1002/...
Italy 98 immunocompromised outpatients with COVID cleared the virus in a median of 17 days. Starting antivirals within 3 days and adding sotrovimab when effective sped clearance more than antiviral alone. www.tandfonline.com/doi/full/10....
New York and California researchers studied mice and found that a subset of regulatory T cells in the skin release natural opioids called enkephalins. These cells calm pain-sensing neurons and prevent inflammation from spiraling out of control. www.science.org/doi/10.1126/...
Stellenbosch and Liverpool scientists studied 34 people and found that even when clotting factors are removed, pseudoserum from type 2 diabetes and long COVID still drives abnormal dense fibrin networks, reshaping how we view coagulation. www.preprints.org/manuscript/2...
Osaka researchers report the FDA will review Shionogi’s ensitrelvir, the first oral drug tested to prevent COVID-19 after exposure. If approved in 2026, it could stop infection before symptoms begin. www.shionogi.com/global/en/ne...
Italy more than 4,000 COVID patients. Scientists found rare variants in the TLR2 gene linked to severe disease. These immune gene changes are scarce in Europeans and absent in Africans suggesting deep evolutionary roots of COVID risk. www.medrxiv.org/content/10.1...
London researchers estimate COVID-19 vaccines cost $79B in 2020–21 but returned $4.8–$37.8T in health and economic benefits. That is $60–$475 gained for every $1 invested, making them one of the best global investments ever. www.medrxiv.org/content/10.1...
Researchers analyzed over 4,000 respiratory samples and built the first global respiratory microbiome atlas. They show the healthy lung is seeded by the mouth, but in pneumonia, COVID-19, and cystic fibrosis this microbial continuity collapses. www.biorxiv.org/content/10.1...
Houston, TX commentary warns that limiting COVID vaccines to only older adults overlooks long COVID and heart risks. Studies show vaccines cut long COVID by up to 95% in adolescents and protect against cardiac complications. www.sciencedirect.com/science/arti...
Madrid study of 88 COVID-19 survivors found no overall immune overactivation two years later but those with fatigue had lower C3 protein and those with dyspnea had lower C3 C5 and C7 suggesting complement links to specific post-COVID symptoms. www.sciencedirect.com/science/arti...
Taipei researchers studied 60 children aged 6 to 18 months after COVID. Over a third had lingering headaches, memory or attention problems. MRI showed enlarged gray matter in those with severe symptoms, linked to visual perception deficits. www.sciencedirect.com/science/arti...
Western Cape South Africa 75 people studied 3 with advanced HIV had months long SARS-CoV-2 infections that generated rare spike mutations later seen in Omicron. Persistent infection in immunocompromised hosts may drive new variants. journals.asm.org/doi/10.1128/...
Great Plains Tribal communities surveyed 843 people in 2023. Over half saw long COVID as a major issue and 40% of those infected still had symptoms. Women and parents living alone with children were most affected. link.springer.com/article/10.1...
Canada interviews with 67 people living with long COVID and caregivers found that fatigue and cognitive issues limit social and leisure life. The loss deepens identity struggles and loneliness, pointing to a need for targeted rehab. www.tandfonline.com/doi/full/10....
In patients with lupus, CAR T therapy caused fewer severe side effects and their immune systems recovered faster compared with lymphoma patients, even though CAR T expansion was similar in both groups. ashpublications.org/blood/articl...
United States editorial warns vaccine trust is at an all-time low. Antivirals like Paxlovid help prevent severe COVID but fail against long COVID. Promising drugs are in development but vaccines remain irreplaceable. www.nature.com/articles/s41...
Seattle researchers argue that COVID-19 vaccine approvals should keep relying on antibody measures, while also adding T cell data and real-world outcomes like long COVID, to ensure vaccines remain protective as the virus evolves. www.nature.com/articles/s41...
British Columbia, Canada 2,212 patients Long COVID was linked to a mean eGFR drop of 2.96 ml per min per 1.73 m2 within one year, larger after hospitalization or diabetes, leaving over 40 percent at risk for chronic kidney disease. www.nature.com/articles/s41...
Clinicians to meet soon on repurposed drug protocols for Long COVID, and minutes later the FDA reminds me that bureaucracy moves at bureaucracy speed. Still, if they keep responding, I’ll keep writing. 😂
Marseille study of 319 COVID patients found 80% improved within a year yet neurological and fatigue symptoms lingered. Men and those with fever or taste loss early in infection faced the highest risk of long COVID. bmcinfectdis.biomedcentral.com/articles/10....
Shiyan China, 54 healthcare workers A 6-week semi-supervised exercise program boosted muscle strength and endurance after COVID-19 and eased depression and anxiety without adverse effects, showing exercise as a safe recovery tool. bmcsportsscimedrehabil.biomedcentral.com/articles/10....
US studies of 1678 healthcare workers find 7.7% report long COVID. Nearly 1 in 4 say symptoms disrupt their work. Doctors and nurses on the frontlines are now among those most affected, often struggling to keep working years later. www.medscape.com/viewarticle/...
In the US up to 23 million people may live with Long COVID. Symptoms like fatigue, brain fog, and anxiety can disrupt work, making accommodations essential for employees to stay employed and recover. www.standard.com/eforms/23084...
Belém Amazon study of 310 adults found fatigue and headache were the most common long COVID symptoms. Vaccination especially with more doses was tied to fewer symptoms with the strongest effect seen in CoronaVac recipients. www.researchsquare.com/article/rs-7...
Rutgers researchers reveal SARS-CoV-2 uses protein NSP14 to add abnormal m7G marks inside host mRNA. This disrupts splicing, promotes intron retention and boosts viral replication. Blocking this step sharply reduces infection. www.biorxiv.org/content/10.1...
Spain, 16 patients with Long COVID and cognitive issues showed reduced brain activity, especially in the cerebellum. Lower activity and thalamic involvement were linked to worse test scores, suggesting hypometabolism drives impairment. www.sciencedirect.com/science/arti...
Mexico City researchers reviewed flavonoid phytosomes, tiny carriers that boost the bioavailability of plant compounds. These nanostructures may enhance antiviral, antidiabetic, and anticancer effects, including against COVID-19. www.sciencedirect.com/science/arti...
Dallas and New Hampshire researchers tested 128 long COVID patients with suspected dysautonomia. Despite heavy symptoms, most showed normal results. Only 16 percent met criteria for POTS, suggesting true autonomic dysfunction is uncommon. www.sciencedirect.com/science/arti...
Sydney researchers show SARS-CoV-2 uses a small RGD motif on its spike to trigger TGF-β signaling. This boosts fibrosis markers and shuts down interferon, weakening antiviral defenses and aiding infection. journals.asm.org/doi/10.1128/...
Charlottesville researchers analyzed over 44 million medical records and found patients hospitalized with severe COVID-19 had a 19 percent higher risk of lung cancer. In mice, prior viral pneumonia reprogrammed lungs to speed tumor growth. www.biorxiv.org/content/10.1...
Basel and Paris researchers review how organoids infused with immune cells can mimic infection, inflammation, and cancer defense in ways mouse models cannot. The goal is to capture immune memory in a dish. www.cell.com/cell-reports...
Rotterdam study of 40 patients found that people with multiple sclerosis show increased circulating B cells and CD4 T cells compared to other CNS autoimmune diseases, marking a distinct immune signature of MS. onlinelibrary.wiley.com/doi/10.1002/...
La Jolla and Chiba researchers show that when TET enzymes fail in regulatory T cells, they lose FOXP3, turn into T follicular helper–like cells, drive plasma cell growth, and trigger autoimmune disease through autoantibody production. www.biorxiv.org/content/10.1...
United States 523,755 people with COVID were tracked in 2022–2023. About 46–61% of adults and 33–47% of children developed long COVID within a year. Risk was highest in older, sicker patients, but overall rates did not rise during Omicron. www.sciencedirect.com/science/arti...
Across 16 countries, 13,656 adults joined a sleep survey. Those with long COVID were twice as likely to face severe fatigue and far more prone to daytime sleepiness and naps than others, showing how persistent the toll on rest can be. www.sciencedirect.com/science/arti...
Ningbo researchers analyzed 107 trials with 101,751 adults and found catechin, Bifidobacterium animalis, and multi-strain probiotics were most effective at preventing respiratory infections, while high-dose vitamin D reduced COVID-19 and flu. www.thelancet.com/journals/ecl...
San Diego company Aethlon Medical secured new US and European patents for its Hemopurifier device aimed at treating Long COVID and COVID-linked clotting disorders, extending protections into the 2040s. www.investorideas.com/CO/AEMD/news...
Researchers screened 16 million compounds and found 3 small molecules that bind more strongly to the SARS-CoV-2 main protease than the repurposed hepatitis C drug boceprevir, suggesting new leads for antiviral development. pubs.rsc.org/en/content/a...
Galveston researchers tested 30 Syrian hamsters with six SARS-CoV-2 variants and found severe smell loss with WA-1, Alpha, Beta, and Gamma, but only mild or no loss with Delta and Omicron, reflecting clear variant differences. journals.asm.org/doi/10.1128/...