The backdoor pathway essentially doesn't happen unless you have an enzymatic deficiency that is quite rare (so not 0% but extremely unlikely)
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what do you mean by a "backdoor pathway"?
sep 7, 2025, 7:38 am • 3 0 • view
This mechanism. It's very important to know that unless you're looking at a human foetus or a koala you won't see it happening. P to DHT is a popular myth / scary brainworm in trans circles but that's just not an actual thing bar an extremely rare deficiency. en.wikipedia.org/wiki/Androge...
sep 7, 2025, 7:47 am • 24 1 • view
Thank you so much for taking the time to help me understand! there's so much more I wish I knew, and I can't help but wonder if certain aspects of my transition would have gone better if I'd had better care and access to appropriate medication .
sep 7, 2025, 7:51 am • 9 0 • view
In general it's at worst a small delay that was introduced, for most cases you just need to start doing the other thing and that's it. Changes are not done and dusted after only a few years despite what those tables that people like want to say.
sep 7, 2025, 7:58 am • 11 0 • view
unfortunately it's already been 10+ years for me. Got chest construction surgery. Not sure there's much else that can be done by now, but honestly I'd be willing to give it a shot. Any advice?
sep 7, 2025, 10:07 am • 3 0 • view
I've known trans women who had breast growth 8-12 years in so I don't think it's too much out of the question basically assuming you have enough E just adding a 200mg prog capsule (the ones that are usually made for vaginal or oral use) rectally every night is a starter
sep 7, 2025, 10:11 am • 5 0 • view
Chiming in to support this: I'm 40, been on HRT for 10 years. Started prog two months ago. I've already had to replace three-quarters of my bras, my breasts have grown so much.
sep 7, 2025, 12:35 pm • 7 0 • view
Similarly, I started progesterone 11 years ago, after over 5 years on HRT, and got major boob growth, having previously plateaued since 1 year on E. So many people endlessly argued with me that P had nothing to do with it...
sep 7, 2025, 4:10 pm • 5 0 • view
congratulations!! yeah, i keep hearing its like a miracle pill for nearly everyone else who's taking it. I'm not sure what my deal is 😅 but I have many other things in my transition that have gone well, so I suppose low breast growth isn't the worst thing to deal with.
sep 7, 2025, 2:05 pm • 1 0 • view
take in the evening/close to going to bed until you know the other effects it can have on you as it can make you a bit dizzy or tired and that's not ideal during the day but ok if you're going to sleep anyway
sep 7, 2025, 10:11 am • 2 0 • view
I'm taking .2 mL of estradiol valerate once weekly at 20 mg/mL (so, 4 mg a week?) subcutaneously, and 200 mg prog rectally every night, yeah. I was worried about it dissolving properly, but I suppose I don't have any reason to believe it isnt, as I've only ever seen white gunk the next day.
sep 7, 2025, 2:04 pm • 0 0 • view
No antiandrogens, i had an orchie in 2019. E levels have been appropriate according to my endo, but yeah, no significant breast growth even after years of prog. I was given medroxyprogesterone in my early transition and a ridiculous amount of spiro (300 mg!!!), my concern is that those may have-
sep 7, 2025, 2:04 pm • 0 0 • view
stifled things when I was younger, honestly. I didn't know any better. didn't have anyone else.
sep 7, 2025, 2:04 pm • 0 0 • view