There's plenty of precedent. George H.W. Bush acted for Regan from 11:28 a.m. until 7:22 p.m. on 13 July 1985. Dick Cheney acted for George W. Bush from 7:09 a.m. until 9:24 a.m. on 29 June 2002. Kamala Harris acted for Joe Biden from 10:10 a.m. to 11:35 a.m. on 19 November 2021.