Unvetted ( by me. Will read) Bnabs each only block 90% of strains. May take multiple courses to cover the gap. #Cure4HIV #HIVCure
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aug 29, 2025, 2:47 am • 1 0 • view
Some caveats. One paper is showing success in "animal models" ugh. Not a big newc deal. We've been able to cure / prevent HIV in apes and humanized mice with bnabs since 2012! Generating them isn't enough. Maintaining them is despite multiple barriers.
aug 29, 2025, 3:12 am • 1 0 • view
Challenges: Generating high enough bnabs in humans is bigger problem. The animal models just aren't accurate. Bnabs are often targeted by the immune system ( anti antibodies) resulting in levels too low to work.
aug 29, 2025, 3:14 am • 1 0 • view
Or the immature lymphocytes needed for their creation, are culled in humans with a certain common HLA types to prevent autoimmune diseases.
aug 29, 2025, 3:15 am • 1 0 • view
There are humans study www.science.org/doi/10.1126/... But it's only stage 1 trial : which is done for safety& proof of concept! I'll be surprised if they've maintained neutralizing levels after 18 mos This might be a breakthrough; But may be a dead end we've reached before. Proof is in pudding
aug 29, 2025, 3:18 am • 1 0 • view
Background: Nobel nominate scientist David Baltimore cured HIV with bnabs in animal models ( humanized mice models and chimps ) using vectured vaccines ( which used muscle cells to turn out bnabs ) in 2012. They were unable to generate high enough levels in humans long-term.
aug 29, 2025, 3:21 am • 1 0 • view
This is a different technology. ( An even harder one to pull off ) ie the scientific achievement here in biotechnology Is still only that. And not an achievement in disease prevention or cure. That requires a high sustainability and replicatabily in a broad number of people that hasn't worked
aug 29, 2025, 3:30 am • 1 0 • view
I hope that stage one trials actually go somewhere. This could be quite a breakthrough.
aug 31, 2025, 10:28 am • 0 0 • view
I don't have an unlocked copy. But I don't think so. A significant percentage of people developed long-term hives. ( Not transient) They have no explanations why or ways to stop it.
aug 31, 2025, 11:35 am • 1 0 • view
Hives can be weird.
aug 31, 2025, 12:54 pm • 0 0 • view