“Hybrid model” is an overstatement! It was just changed because some very basic things weren’t taken into consideration at trial planning ! #NephJC

It’s not that they were not considered - Laura Denver who designed TIME (where they did enrol the right N) was involved Just that their assumptions did not bear out. Nephrologist and staff inertia and closed mindedness killed the trial #NephJC

*Laura Dember I meant #DamnYouAutoCorrect

I can write down the model to analyze this in #rstats. With the numbers they ended up recruiting, one has to have lot of faith to believe in the estimates #nephjc