We found no association between ME/CFS and KIR gene content or copy number variations. However, our data suggested that specific KIR alleles at loci encoding inhibitory receptors were associated with #ME/CFS, which was further supported by allelic haplotype analyses. Three alleles were more frequent
in patients, i.e. KIR3DL3*002 (OR = 1.43, 95 %CI (1.09–1.86), p = 0.009), KIR3DL1*020 (OR = 2.20, 95 %CI (1.19–4.06), p = 0.01) and KIR3DL2*009 (OR = 1.56, 95 %CI (1.09–2.23), p = 0.01), while two alleles had a reduced patient frequency, i.e. KIR3DL3*013 (OR = 0.60, 95 %CI (0.42–0.86), p = 0.005)
and KIR3DL2*010 (OR = 0.46, 95 %CI (0.30–0.71), p = 0.0005). Our data support an involvement of NK cells in ME/CFS. #ME/CFS #KIR #NKcells