I don't really get why he's doing it, but it should probably go well. This is a bad F2 field and next year's won't be strong. Assuming TWG knows that they're supposed to buy him some poor unemployable child's ride mid-season as prep, I think he could have multiple wins by the end of this year.
Also he is ultimately an adult and F2 drivers are ultimately not. There are plenty of ways it can go wrong, but unless he completely fails to gel with the car and tires, he should be winning enough to make all of the random engine failures irrelevant.
i just don't think he really wants to be an indycar driver anymore and even if he did i think he is best served getting out of the andretti indycar team. and you are right this is the weakest f2 lineup for a good while he will be fine