While Peter Attia calls 500 mg a “homeopathic” dose, I disagree. In a healthy individual shooting for gut AMPK activation, a boost in incretin hormones, and mild glycemic benefits, 500 mg ER is plenty. Low doses will also minimize risks from drug effects outside of the gut. 🧪
We don’t yet have RCTs that can confirm the benefits in healthy individuals, and we likely won’t for quite some time. But with current evidence pointing towards benefits across many aging organs, one must also consider the risks of waiting for that evidence to exist.
Key Sources: 🧪 📰 Metformin MOA: www.nature.com/articles/s41... 📰 Metformin promotes metabolic health, prevents diabetes, and promotes modest, durable weight loss: pubmed.ncbi.nlm.nih.gov/11832527/ 📰 Metformin reduces systemic inflammation: pubmed.ncbi.nlm.nih.gov/33412927/
Key Sources 2: 🧪 📰 Low dose metformin improves healthspan and lifespan in mice: pmc.ncbi.nlm.nih.gov/articles/PMC... 📰 Metformin decreases PD risk only when used at low doses: pmc.ncbi.nlm.nih.gov/articles/PMC... 📰 Metformin blunts exercise adaptations: pubmed.ncbi.nlm.nih.gov/31557380/
Key Sources 3: 🧪 📰 Metformin blunts exercise adaptations: pmc.ncbi.nlm.nih.gov/articles/PMC... 📰 The case against metformin in healthy individuals: drglorioso.substack.com/p/should-you...