Sometimes, people are so fed up that they only eat a little!
Research Scientist/1st employee at Sanmai. Transcranial focused ultrasound neuromodulation. Medical neurotech. Bylines: Neurotech Reports. Alum, UMich. Opinions = own 📍 Silicon Valley ☀️ https://www.linkedin.com/in/sharenarice/
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Sometimes, people are so fed up that they only eat a little!
A former boss said I am the only person they know who can put an exclamation point after every sentence and have it sound just like me!
Very happy about: having a 10/10 discipline level with everything I set out to do today!
Coworker: Where do watermelons grow? Me: 🎵 Down by the Bay! 🎶
I am not a physicist, yet... -My parents both have associate's degrees in physics. -I enjoy making a wordplay that my sister is my astrophysisister... because she totally is. -My boyfriend is a physicist. -My favorite former roommate was a physicist. Happy to collect more #physics connections!
If you are a physicist, let's collect each other! Along with neuro people, I have a tendency to collect physics people! #physics
I am curious about the nuances of how the economic losses and gains were counted and accounted for, when it comes to miles traveled and by which type of vehicle (car vs bike). Happy to have a full recovery! Yet I hope that the bikers stay safe!
This makes sense: about a year ago, I was hit by a car while riding my bike in California. Some economic gains for society: -Needing to spend 3 days in the hospital -Several follow up medical appointments -Hiring a personal injury lawyer -The insurance settlement -Having the bike repaired
We picked up something ASAP: it was maple syrup!
Currently happy about: my robotic vacuum mop’s 163 hours of cleaning over the past year! It is wonderful to have the floor automatically cleaned every day!
Currently happy about: Apple device software update
Proud to be one of yours, as well! Clubhouse is how I first learned you existed!
Currently happy about: chia pudding with strawberries
I know the Clubhouse app was something of a flash in the pan in its remarkable heyday, yet four years later, I somehow find myself in a dedicated conversation with people I originally met via Clubhouse on the phone or in real life at least once per week! #clubhouse
Currently happy about: HTML CSS #webdesign
Currently happy about: learning the key differences between command + click and shift + click in MacOS
Currently happy about: free access to @oreilly.bsky.social via my local library
One way could be to have more blue belly (aka western fence) lizards around. There is a component of their blood that neutralizes the Lyme disease-causing bacteria in the tics that bite them. Next time you go outdoors and see a #lizard like this, thank them for preventing the spread of Lyme!
Currently happy about: designing with @figma.com
Currently happy about: watermelon coming to my office! 🍉
Currently happy about: changing my Slack notification tone so it is no longer the default
Enjoyed a rowboat and conversations with @malenarice.bsky.social over the weekend!
Currently happy about: PicoScope #electronics
💻 Ryzen shine ☀️
Currently happy about: improving the usability of a test setup
Publishchute or parachute! 📑 🪂 #publish
It is amazing how many brilliant people I know say that they don't learn the fastest, but they stare at things for a long time and learn very deeply. I think System 2 thinking (referencing Thinking Fast and Slow) is underrated. #thinking
Currently enjoying: not earl grey tea, not Earl Gray tea, but... Earl Grey tea. #tea
Welcomes! :)
People say "Thanks"! Thus, I say, "Welcomes"!
Updated Sharena GPT, which I created to discuss neurotech and careers! #neurotech #neuroscience chatgpt.com/g/g-ySfoLIfb...
Used this board to create a new floating bookshelf over the door! Thus opening doors to opening books! Materials to build the bookshelf enabled by my partner, @kylekabasares.bsky.social, smiling orange bookend was a gift from @malenarice.bsky.social #bookshelf
Currently happy about: fitting a 72 inch wood plank in the backseat of my sedan without needing to use the trunk
Sanmai's feature in Bloomberg: www.bloomberg.com/news/article...
Jay's talk at BrainMind: www.youtube.com/watch?v=RCep...
Sanmai's website: sanmai.tech
You can learn more from the links to the following in the comments: -Sanmai's website -Sanmai's Co-Founder, CEO, and President, Jay Sanguinetti, speaking at the BrainMind Summit -Sanmai's article in Bloomberg I am equally humbled and inspired to be Sanmai's first employee.
I also have enjoyed collaborating with BrainMind, Acacia Clinics, and Shinzen Young. Sanmai has a well-aligned community of investors and angels. Further, Sanmai was in this past cohort of the One Mind Accelerator, a fruitful experience.
Our team is lean, talented, and mighty. Sarp Satir, Quentin Todd, Lisannette Adelaida Ruiz, Yao-Sheng Tung, Christina Le, Shauna Legsdin, and I have put years of effort into building the company and advancing the technology.
Working to develop a new neurotech medical device is a long road that truly takes a village. Sanmai was founded in 2020 by Jay Sanguinetti, Taylor Kuhn, Tim Mullen, and Chris Daft, along with Tomokazu Sato, Ashish Parikh, and Will Wu. We have Jud Brewer, MD, PhD, as our Chief Medical Officer.
Sanmai is working to translate cutting-edge neuroscience into clinic-ready tools. While our device is investigational and not currently available for commercial use, our focus is rigorous trials, FDA approval, and making neurotherapies that are safe, effective, and accessible.
We’re honored to welcome @reidhoffman as the lead investor in our $12M round and to Sanmai’s Board of Directors. Reid’s belief in our mission, alongside board members Jay Sanguinetti, Kit Kaufman, and Charles Cadieu, brings deep wisdom across strategy, law, AI, and ultrasound innovation.
Lotus a first-in-class transcranial focused ultrasound system, enabled by AI and built to help clinicians care for their patients. With acoustic precision and noninvasive individualized targeting, Lotus makes neuromodulation both simple to use and scalable—unlocking new potential treatments.
Sanmai is a Public Benefit Corporation developing a new category of brain therapeutics. We are creating a clinical platform called Lotus, which you can remember because Lotus may help people flourish. And because Lotus sounds like low-intensity transcranial ultrasound!
In a world with a growing mental health crisis and a growing number of people experiencing neurodegeneration, how might we bridge the gaps? After years of quiet, dedicated work, I am excited to talk more about Sanmai. #neuroscience #neurotech #neuroskyence #brainhealth #neurology #psychiatry
Currently enjoying: grilled cashew cheese sandwich with sourdough bread and a pinch of cayenne pepper #grilledcheese
I have been rapidly multiplying the media by which I can produce multimedia! #multimedia
Owen GPT, the GPT version I made of my friend and colleague, @owenmuir.bsky.social, has had over 300 conversations! For additional extensions of how Owen thinks, you can check out The Frontier Psychiatrists: a newsletter about mental health, including health economics and the insurance system.
Currently happy with: buckwheat soup
The house always wins. And the house is the infrastructure! #infrastructure
Open access version of the Bloomberg article: archive.ph/RRUKP
It is a tremendous honor and responsibility to be bringing Sanmai's devices to life. What is Sanmai doing? Using beams of focused ultrasound to change brain activity. This could potentially treat neurological and psychiatric conditions. Delighted to have Reid Hoffman's support on this journey!
Feeling very fancy and clean with my CleanSense DIB-1500
Finally, my primary instrument (the oboe) has a good visual pun to go along with it!
Hooray! The oboe is my primary instrument! 🎶
Currently happy about: wrist cushion. I used to think it was a superfluous thing, but after becoming a power user of a computer mouse, a wrist cushion makes so much sense!
Glassworking clearly went well. Fired up to do more. Have some beads in your feeds! #glasswork
BAGSMART Rolling Backpack for Women, Travel Carry-On Backpack with Wheels, 17 Inch Large Roller Wheeled Daypack with Two Packing Cubes, Black. Because it fits under airplane seats and therefore counts as a personal item on flights!
But now, I have a car and sold my bike. And I regularly work with two laptops and a tablet. These are rather heavy. Rolling backpack? We are so back! #rollingbackpack
I had rolling backpacks during elementary school, middle school, high school, AND undergrad! Why did they stop during grad school? I lived in Michigan, where it snowed, and biked nearly every day. Even when it snowed. #rollingbackpack
I am very skeptical of longevity experts who are under 90 years old
Currently working on: a firm science - neuroscience and graphic design - a hard art
Article: sharenarice.substack.com/p/furthering... In learning about solutions that can create stability assurance for STEM trainees, and we would love for university leaders and trainees alike to share and join the conversation. #academia #universities #highered #gradschool #postdoc
How can universities and STEM trainees collaborate to close funding gaps while unlocking new kinds of research and career growth? Delighted to work with @kylekabasares.bsky.social to bring this article to life. 🔗 This article is freely available for anyone to read. Link in the comments.
Currently happy about: Elusive Cures by @nicolecrust.bsky.social ! Listening to the audiobook. It feels specially done because the author not just written the book, but has also taken the time to record it in her voice.
Good things happened at work, and we had a lot to do. We celebrated with creme soda.
It is one of those times- need to create designs on the big screen, send the designs to other people for feedback on a smaller screen, and edit folders/documents that these designs go into on another small screen. Thus, this setup feels like a UI design for creating UI designs!
Last week, I collected a new mouse and a new keyboard with customizable buttons and the ability to switch their connectivity between 3 different computing devices. Surprisingly excellent productivity/work enjoyment upgrades, especially with how much digital design I have been doing!
Currently happy about: designing in Autodesk Fusion #autodeskfusion #design
This is the cake Bill's daughter made for his 72nd birthday party, when Bill joked he was turning 27. I guess when life gives you lemons and life is like a box of chocolates, you never know what you're going to get. Maybe it's not really lemonade, it's lemon chocolate cake.
Bill loved lemon chocolate cake. The first time he tried to order some from a cake store, they said they did not do lemon chocolate, as those flavors don't go together! Bill ordered it anyway. It was very good. So we had lemon chocolate cakes at his birthday parties!
Bill is no longer with us. He contributed so much to usability at Apple. Even the way Bill designed his home and how he made jam from the neighbor's excess plums had such well-thought attention to user interaction. This NYT article is pretty good too: www.nytimes.com/2025/06/07/t...
Currently grateful for: Bill Atkinson. He was the person who collected me from the airport when I was moving to the Silicon Valley. I visited his house several times, met his family and dog, enjoyed learning from his stories. We were friends. General Magic indeed.
Yet another alternative source of funding: internships/fellowships with companies. The Momental Foundation is one example of how this can work. Pair PhD students and postdocs with quantitative skills with humanitarian projects in deep tech and hardware startups: www.momentalfound.org
Turns out the tungsten needs to be pushed in more than in the last post's picture. Made progress in welding. First, with beads of steel, then welding two plates together, then a corner. The metal holds together! It looks nice and neat on the inside! #welding
Being a graduate student instructor would ideally not be the only way outside of grants for grad students to fund their work. Universities have multiple responsibilities besides teaching which they need personnel for. Hands-on experience can help both the trainee and their university.
Thus, if biomedical science trainees were working part-time in the university hospital for a year or two as medical technicians, that could potentially be a source of funds. For people in other sciences, perhaps they could cross-train in intellectual property and work part-time with tech transfer.
I find it amazing that a PhD can go for years working with EEG or MRI for neuro research, yet despite their works with the techniques, they are not considered qualified/certified as EEG or radiologic technicians. Yet the medical trades provide stability for 2-year associate's degree holders.
In the biomedical sciences, it could be if the scientists are normally cross-trained as medical technicians. If they are part of the university hospital healthcare system, they can provide an essential service, learn techniques, and gain a better sense of how to meet clinical needs as innovators.
Currently happy about: learning TIG welding with mild steel! I do not have an axe to grind, but I had tungsten electrodes to sharpen
Currently happy about: learning with a RISC-V workshop at @ucsantacruz.bsky.social Silicon Valley Extension!
Sending you the closest things I can find in emoji form, along with joyful music: ☕🍞✨🎵
Currently happy about: börek and Turkish coffee
All happy with a blackberry malt at the company office 🥤
The article is free for anyone to read. Lisa Shafer of Biogen discussed neurotech and biopharma interactions, and investors highlighted a shifting financial environment. While I have been to various neuro conferences this year, sadly, none of them had any personnel at all from the FDA or NIH
www.neurotechreports.com/pages/BMF25r...
Good times and learnings with Neurotech Reports's 8th annual Bioelectronic Medicine Forum at the New York Academy of Medicine! I wrote a conference report on the discussions of policy shifts, link in comments.
frogress = the leap forward when a tadpole undergoes metamorphosis
Currently happy about: Goo Gone's ability to remove Sharpie marks, including metallic-colored Sharpie marks
Doing the tai chi of the lumber at the Maker Nexus wood shop! “One smooth continuous motion” is often the mantra to keep in mind #woodworking #makerspace
Good times machining in metal shop at Maker Nexus!
It is called the San Francisco Bay, rather than the San Jose Bay
Update: the rain washed my car!
Currently appreciative of: Adobe Illustrator 🎨 Enjoying vector graphics creations!
Currently happy about: rain in Sunnyvale As I like to say, the clouds are a sunny veil 🌦️, their parting will be a sunny unveil! 🌤️☀️
You can just build stuff
Realized I could use this wooden board to make a moveable TV stand out of my rolling whiteboard! Added a few screws to stabilize the setup. This whiteboard assembly now also serves as a better room divider than before! #whiteboard #tvstand
currently appreciative of: how fruits and vegetables can be blended into smoothies
Machining metal on a Bridgeport mill is such a thrill!
