Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant hematopoiesis. www.cell.com/trends/cance...
Independent Group Leader at the MPI-IE passionate about mechanisms governing embryonic development with a focus on transposable elements🧬 Postdoc @MundlosLab 🇩🇪| PhD from @Bourchis lab 🇫🇷| She/her https://www.julianeglaserlab.com/
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Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant hematopoiesis. www.cell.com/trends/cance...
We take for granted that our hands have two sides and can articulate in an endless number of ways. But what about a fish’s fin? Can a fish know something “like the back of its fin,” or have its future told with a fin palm reading? Check out this bluetorial to find out 👇🧪🧬🐟 doi.org/10.1101/2025...
🚨 Job Alert: we seek a Lab Manager for @juliabatki.bsky.social's new group (start Mar 2026), which will study cell fate regulation during organ development. Join the Batki's group to drive experiments & lab operations! Apply at: www.fmi.ch/education-ca...
Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026). For more information, please contact: marie-helene.verlhac@college-de-france.fr
The peppered moth is a textbook example of natural selection, its colours shifting with the soot-darkened trees of the Industrial Revolution. But the genetic secret behind its “dark” form took 150 years to uncover: a new “jumping gene” that rapidly took over the population. 🦋 tinyurl.com/4zrc4e93
I am excited to share that I will join the Friedrich Miescher Institute @fmiscience.bsky.social in Basel as a group leader, starting my lab in March 2026 🎉 We will explore cell fate regulation during organogenesis, with a focus on how cell elimination underlies the emergence of functional tissues.
Congratulations Julia!!!! 🍾This is so well deserved! I am really happy for you and look forward to some Basel-Freiburg Dev Bio interactions :)
Wow congratulations Can!!! Very well deserved 🥂
🧬 New study from the Kinkley Lab! 🧬 In collaboration with the Vingron and Hnisz labs at the MPIMG the team has gained new insights how the epigenetic reader PHF13 regulates it´s affinity to bind to chromatin. Read more: www.molgen.mpg.de/2025-07-28-o... Congrats to first author Francesca Rossi!
To all post-docs: The Genome Biology dept @embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Grateful and excited to launch the Otsuki Regeneration Group at the Hubrecht Institute! 🔗 www.hubrecht.eu/research-gro... We study how tissues regenerate - and use those principles to build 3D tissues in vitro. Full announcement: www.linkedin.com/in/leo-otsuk... @hubrechtinstitute.bsky.social
Our new story in Nature Genetics: endogenous retroviruses can produce viral-like particles in the embryo resulting in apoptosis and congenital malformation. If this would happen in human, it wouldn't leave a trace. No WGS or other analysis would identify this. www.nature.com/articles/s41...
😍😍😍 Thank you Anna!
So happy to see the illustration of our work featured on the cover of @natgenet.nature.com 😍 It represents digits desintegrating into viral like particles. Thank you so much @annaamonaco.bsky.social for making this design!
It's that time of the year - @mdc-berlin.bsky.social Pride Symposium in its 4th edition with great talks and discussions on intersectionality and DEI in general. As Neil Young said on Waldbuehne the other day - "Times are rough, we gotta look out for each other" 🫶 #MdcDiversity
Thrilled to see our revised preprint now published in Nature Ecology & Evolution! If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers! www.nature.com/articles/s41...
Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
How did the bat get its wings? New research from a collaboration between the labs of Stefan Mundlos (MPIMG), Dario G. Lupiáñez, and Francisca M. Real (@cabd-upo-csic.bsky.social) show how genetic programs were reused during the evolution of mammalian flight. --> www.molgen.mpg.de/news-2025-fl...
Exactly two weeks left to submit your abstract to the EMBO Mobile Genome Workshop. ☝️this year we will select from abstracts 2 “long” talks to highlight last minute breakthrough from early career scientists. Apply! July 29th
🏳️🌈Our editor @slefkopoulos.bsky.social discussed with @jzylicz.bsky.social about the importance of celebrating Pride, representation in science, and more! Happy Pride! Read here: rdcu.be/ewfba bit.ly/3Uc72TO
Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc! Multiple positions across multiple groups @mrc-lms.bsky.social Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇 lms.mrc.ac.uk/work/vacanci...
Also, in Bl6 mice, the MusD is methylated and silenced despite being inserted at the same position (figure 1 and reported previously in Kano et al.)- this is caused by a polymorphism between mouse strains (what exactly is still under investigation 😉)
Thank you for your comments and thoughts! In the paper we tested whether the MusD will respond to enhancers at 3 other developmental loci and it does! So we don’t think it is related to Fgf8 landscape but rather the MusD promoter itself
Thank you! Very interesting papers, thanks for sharing. I am curious what makes TE promoter responsive to any (?) reg. input (the viral origin?) & how common it is!! A recent paper from @ksiudeja.bsky.social lab show co-option of reg. sequences by an LTR in flies (academic.oup.com/nar/article/...)
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. www.nature.com/articles/s41...
Thank you, Martin!! 😊
🎉ONLINE @natgenet.nature.com 📰Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes. By @julianeg.bsky.social, Giulia Cova, Stefan Mundlos and colleagues. ⬇️ www.nature.com/articles/s41...
Thanks Raquel 😊
Thank you Katerina!!!
Thank you Olga!
Congrats Adri!!! Very well deserved!
Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...
Also, check out the News & Views summarizing our findings, written by Youjia Guo & @themodzlab.bsky.social 🤩🤩 www.nature.com/articles/s41...
My newly established lab @mpi-ie.bsky.social will investigate these questions & everything related to TEs in mammalian development. Please get in touch if you are interested! 10/10
Lastly, this work raises many new questions! Can VLPs cause other developmental pathologies? Why are certain developmental cells more vulnerable to VLPs than others? More generally, how do TE insertions contribute to pathological and healthy developmental phenotypes? 👇👇 9/
This work was done in @stemundi.bsky.social lab @molgen.mpg.de, funded by @hfspo.bsky.social . THANK YOU to all authors & the amazing colleagues I was very lucky to work with❤️ We also thank the reviewers for their supportive comments & helpful suggestions, which improved a lot our manuscript! 8/
Our findings also provide a mechanism by which TE insertion uses the local regulatory landscape, restricted by 3D genome boundaries. We show insertion of the MusD in the neighboring but separated Lbx1 regulatory domain leads to expression in a different limb developmental population 7/
Overall, we describe how VLP production in post-implantation embryos can interfere with organ formation 6/
But how do MusD VLPs in the cell drive this phenotype? 🤔 We generated 5 mutants of the MusD sequence. Our results showed that the Gag capsid is essential to drive a phenotype, but is not sufficient to generate the severe Dactylaplasia phenotype when reverse transcription is prevented. 5/
VLPs in the apical ectodermal ridge (AER) cells of the limb are toxic: we observed DNA damage and apoptotic cell death ☠️ at the time of digit outgrowth, causing the limb phenotype observed in adult mice 4/
Using confocal and electron microscopy, we showed that MusD expression in the same cells as Fgf8 leads to the production of intracellular viral-like particles (VLPs) in the embryo 🦠 3/
TE insertions can disrupt genes or act as enhancer/alternative promoters. Here, we show that the MusD insertion does NOT affect local gene expression. Instead, it is incorporated into the Fgf8 regulatory domain and adopts its enhancers, causing its co-expression with Fgf8 2/
We used a model of TE-linked limb malformation in mice to gain insight into transposon biology during post-implantation development. A MusD element insertion upstream of the Fgf8 gene was reported to cause Dactylaplasia (Kano et al. 2009, Schwarzer & Aktas thesis dissertations) 1/
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Congratulations!!! Really cool story!
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
Thank you, Adri 🥰 Hope you are doing great, and that we can catch up soon!
Very excited to have joined the @mpi-ie.bsky.social ! Thank you for the warm welcome 🤩🤩
Thank you!!
Thank you, Max!!!!! 😁
Thank you, Agnese!!! Hope to meet you soon again!
🚨 Check out the latest from @trono-lab.bsky.social showing how evolutionarily young transcription factors contribute to human cell cycle regulation! Brilliant work led by Romain Forey and Cyril Pulver, now published in Cell Genomics. Check it out ! www.cell.com/cell-genomic...
⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
Mustering the courage to share my latest scicomm endeavour: I channelled my love for writing into a blog where I can hopefully bring the marvels of evolutionary biology and non-coding DNA to all Science lovers! darkgenomevo.wordpress.com/2025/06/22/i...
Postdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro
Amazing!! Félicitations Maheva! 🥂
Textbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22
Congratulations @ksiudeja.bsky.social and all authors! It’s a very cool story!
Happy that our preprint from early this year, uncovering the regulation a somatically "hot" endogenous retroelement locus, has now found its home in @narjournal.bsky.social. "TEsky" doi.org/10.1093/nar/...
Transitions in development – an interview with Jan Żylicz We met with @jzylicz.bsky.social (reNEW @ucph.bsky.social) on Teams to learn more about working abroad, finding a good mentor and his career path so far: journals.biologists.com/dev/article/...
Save the date 📅! Our TriNational #devbio #stemcell Meeting 2025 will be held in Freiburg on Sept. 19th. As always, participation is free and talks will be selected from early career scientists. Joun us 😊 Info: devstemcell.org/home @biozentrum.unibas.ch @uni-freiburg.de @igbmc.bsky.social
Students (Master's/PhD), do not miss this fantastic Developmental Biology course of @sorbonne-universite.fr and @institutcurie.bsky.social - It is FREE and open to international students, however, room and board + travel are not included. training.institut-curie.org/courses/deve...
If you are interested by epigenetics, early human development in excellent scientific environment in middle of Paris, we are recruiting a postdoc. app.beetween.com/WeaselWeb/p/... Don't hesitate to apply or share the post !
This is great news for Freiburg and the #Epigenetics community in the region! Congratulations to @simonelsasser.bsky.social – and we say welcome back to Freiburg. 😀
Congratulations @henriniskanen.bsky.social and the whole team!
Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social: www.biorxiv.org/content/10.1... 🧵 below
Did you know we have a dedicated Jobs Board? Whether you're looking for your next job, or you have an open position to advertise, do check out our Jobs Board: thenode.biologists.com/jobs/ #DevBio #StemCells
Check out the work of Mikie, Tobi, @danielibrahim.bsky.social & al. on enhancer conservation despite sequence-divergence in the developing ❤️ of 🐭 and 🐣 It was great to see this story unfold over the past years! Congrats to all authors!!!
Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury. www.nature.com/articles/s41... A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka. 🧵1/14
New preprint of @trono-lab.bsky.social and my PhD work! By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity. 🫀heartbeat on 🔁 repeat www.biorxiv.org/content/10.1... #TEsky
A Tenure-track Junior Professor Chair (CPJ) is now open at @neuropsi.bsky.social Focus: Multi-omics cellular atlases of brain development Application details & deadline coming soon, stay tuned! @univparissaclay.bsky.social
📣 🥳 🧑💻 Our department is hiring: Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark Deadline June 1st Thanks for sharing! mbg.au.dk/en/news-and-...
We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵
I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...
Congratulations Raquel!!! Great to see it out and so looking forward to reading it in details!
The Robson lab's second paper! A truly fun collaboration with an unexpected and important finding - progenitors reconfigure 3D genomes organisation to commission loci for future cell fates. A heroic amount of work from a rockstar team.
🚨 Preprint 🚨 Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens! doi.org/10.1101/2025...
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
Beautiful work 🤩
Fantastic, congratulations to all authors!!! I love this story!
Proud to share my main postdoc work! 🧠 I asked: How to build a #brain that lead to #individuality? We show that adult brain wiring isn't fully predictable from genes or environment alone— the #stochastic nature of #development is a key third factor. #NatureNeuroscience www.nature.com/articles/s41...
Congratulations Maheva!!!
The awesome Helene Kretzmer and I are looking to recruit a join computational PhD student. Applications will be evaluated on a rolling basis, so don't wait! Any questions get in touch. We are looking forward.
Come to Lund! We are looking for a postdoc to join the team. #transposons #epigenetics
A beautiful example of how cautious interpretation of an artifact leads to important results for the scientific community👇Congrats @konrad-chudzik.bsky.social @drmrobson.bsky.social and all authors!
A bit late on this but happy to share one of the last project I participated in the Cantù lab! Thanks to @annanordin.bsky.social, @claudiocantu81.bsky.social and all the other people without whom this project would have not been possible.
Interested in the latest advancements of #epigenetics of #mammalian early embryogenesis? Then join our upcoming mini-symposium in Freiburg! 📅 April 24, 2025, 14:00-19:00 PM 📌 Max Planck Institute, Freiburg (only on-site!) 🛠️ Organized by: @iovino-lab.bsky.social Register & join free of charge.
Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social
Celebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth
Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇 tinyurl.com/PostdocEvoEp... Repost are appreciated
Congrats Diego!!
The Paris-Saclay Institute of Neuroscience @neuropsi.bsky.social has launched a call for new group leaders. Please spread the word! deadline May 30 neuropsi.cnrs.fr/wp-content/u... @cnrs.fr @univparissaclay.bsky.social
#StandUpForScience👩🔬👨🔬📢Scientists at the Max Planck Institute for Molecular Genetics in Berlin, including our managing director, show solidarity with our colleagues in the US who are protesting against the attacks of the current US administration. @standupforscience.bsky.social @maxplanck.de
Indeed! 🦀♥️
Very elegant work using long-read sequencing to unravel new principles of how new KZFPs emerge to repress ERVs 🦀🦠
Congrats Melania et al.!!! Happy to see it out and looking forward to reading it in details 🤓
A warm welcome to @canaztekin.bsky.social joining FML Tübingen! He's leading the "Structural Regeneration" group, studying limb regrowth in different species. Learn more about his fascinating research shorturl.at/vIFID #regeneration #evolution #FML #MaxPlanck #biology
‼️Save the date‼️The new Max Planck #Postdoc Program kicks off its first call for applications from April 1, 2025; applications can be submitted until May 13, 2025. mpg.de/en/max-planc... #ScienceCareer
