Jason C. Cole (@theduckmachine.bsky.social)
Just caught up with the Metro bank semi. Go Hampshire!! ,๐
Crystallographer, Software hacker and cricket lover. As is probably evident from my handle, I enjoy batting but I'm not very good at it. Views are my own.
320 followers 575 following 628 posts
view profile on Bluesky Jason C. Cole (@theduckmachine.bsky.social)
Just caught up with the Metro bank semi. Go Hampshire!! ,๐
Jason C. Cole (@theduckmachine.bsky.social)
Nottinghamshire deserves better than people like this. www.bbc.co.uk/news/article...
Emily Mullin (@emilymullin.bsky.social) reposted
The CDC is in chaos. If youโre a current employee and would like to share information anonymously, please reach out via Signal: emullin.06 www.wired.com/story/center...
Jason C. Cole (@theduckmachine.bsky.social)
I am yet to see Marcus Stonis bat well in a chase. Perhaps he'll do it today in a dead rubber game where he came in with little score pressure, but ... ๐
Elizabeth Ammon (@elizabethammon.bsky.social) reposted
Mark Wood boosts Englandโs Ashes hopes as he plans Durham return www.thetimes.com/article/368a...
Jason C. Cole (@theduckmachine.bsky.social)
Ah. Played my last midweek evening cricket game of the season yesterday. Today, it feels very Autumnal.. have pity at the moment with any cricket playing friends .. we see the long dark winter ahead of us. ๐
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
A #DrugDesign framework that uses GOLD docking, OpenEye tools, and AI to generate molecules using fragment-based drug design and multi-parameter optimization ๐ The STELLA framework delivered 217% more hits and 161% more unique scaffolds than existing methods. ๐ ccdc-info.com/45B4rtn
James Alistair Henry (@jamesbluecat.bsky.social) reposted
I love our town fair day, but there's always one violent idiot who has to ruin it for everyone, trundling around making threats.
Jason C. Cole (@theduckmachine.bsky.social) reply parent
The first lawsuit, where Google is sued because they gave bad information like that ( e.g. mistaking peanut allergies for some other seed allergies) is coming.
Jason C. Cole (@theduckmachine.bsky.social) reply parent
The funny thing though, the Tesco staff often haven't a clue.
Louise Dawe (@louisedawe.bsky.social) reposted
I'll be attending the European Crystallographic Meeting in Poznan, Poland next week. Please stop by the IUCr booth if you would like to chat about publishing your work related to structural science, crystal engineering, and materials in @actacrystb.iucr.org!
Jason C. Cole (@theduckmachine.bsky.social)
Sounds like someone strangled a cat in the mid-innings break at Lords tonight in #TheHundred .. awful singing!
Jason C. Cole (@theduckmachine.bsky.social)
Hi @kevinhowells.bsky.social .. enjoying the Comms. My favourite village name has to be Pratt's Bottom in Hampshire. There's also a Lower Pratt's Bottom. Fortunately there's no Upper Pratt's Bottom.
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
The Cambridge Structural Database has been updated, adding 20,370 structures (22,998 new entries)! ๐ This blog highlights a few examples from this update, including a stunning tetranuclear Ru cubane with three polymorphic forms ccdc-info.com/4mkyg7j ๐คฉ #Crystallography #CompChemSky
Jason C. Cole (@theduckmachine.bsky.social)
Tired, but me 1. unwanted Budlea 0. Can't believe how quickly they grow.
Jason C. Cole (@theduckmachine.bsky.social) reply parent
Trump was played like a virtuoso's fiddle.
Jason C. Cole (@theduckmachine.bsky.social) reply parent
Heard it in Cambridge too.
Jason C. Cole (@theduckmachine.bsky.social) reply parent
If a ball pitches off the cut strip, it's a no ball rather than wide, which to me also seems very unfair on the batter!
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
๐Are you a school #ChemistryTeacher? Use this free learning module to expose your students to the concept of crystallization through exciting practical activities! ๐ ccdc-info.com/4mK9vBl We will be at the #ECM35 Crystallography in School workshop later this month๐ ccdc-info.com/3JhyI7v #iTeachChem
Derek Lowe (@dereklowe.bsky.social) reposted
Slightly diminish a band: Pigiron Dan Muttering Heads
Jason C. Cole (@theduckmachine.bsky.social) reply parent
Wimply Red
Jason C. Cole (@theduckmachine.bsky.social)
The ladies blind cricket team are trying to raise funds to play in the inaugural Women's T20 world cup for the blind. Hope they make their target. www.justgiving.com/page/paul-to...
Jason C. Cole (@theduckmachine.bsky.social) reply parent
I do wonder how long it is before global pharma companies who have large research investment in the US just go, that's enough and relocate to elsewhere again. I presume they are holding off at the moment until the midterms, but who knows.
Jason C. Cole (@theduckmachine.bsky.social)
I imagine @privateeyenews.bsky.social will be smiling.
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
Recently published by @pubs.acs.org, researchers used CSD Ligand Overlay to study the main pharmacophoric interaction points with ATP binding sites, useful for the design of new ROCK inhibitors. ๐Read the full paper in ACS Omega at pubs.acs.org/doi/10.1021/... #DrugDesign
Derek Lowe (@dereklowe.bsky.social) reposted
What, about 2 1/2 months?
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
Should all chemists learn how to code? What soft skills are most valued today? ๐ค A panel webinar for anyone looking at career paths after a chemistry degree, as well as the educators that are guiding them. Sign up here๐: bit.ly/3ZUe17o #ChemSky #iTeachChem #ChemCareers
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
This guide (produced in collaboration with Ouvry, NRG Therapeutics) shows the preferred conformation of common groups used in drug design. These preferred angles have been deduced from millions of experimentally observed instances in the CSD. ๐ bit.ly/3UxTbY5 #CompChemSky #DrugDesign #ChemSky
Jason C. Cole (@theduckmachine.bsky.social)
Don't get tripped up at the pub quiz. If the question is "Who is England's most successful football team manager?" The answer isn't Alf Ramsey. It's not Gareth Southgate. It's Sarina Wiegman. #Euro2025 #ENGvESP
Jason C. Cole (@theduckmachine.bsky.social)
Guess no bookmaker is taking bets on #SPOTY team of the year now. #Euro2025Final #ENGvSPA
Jason C. Cole (@theduckmachine.bsky.social)
Well Done Lionesses!!!!!! #ENGvESP #Euro2025
Jason C. Cole (@theduckmachine.bsky.social)
Live scenes from the Spanish pre-final training session. #Euro2025
Jason C. Cole (@theduckmachine.bsky.social)
More dives from Spain than Tom Daley has made at the Olympics. #ENGvESP #Euro2025
Jason C. Cole (@theduckmachine.bsky.social)
@norcrosscricket.bsky.social I believe Nelson was said to have one eye one arm and one ar*ehole. #bbccricket
Lisa Jarvis (@lisamjarvis.bsky.social) reposted
Welp. www.wsj.com/health/healt...
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
From @apoethig.bsky.social,โฌ [2]rotaxanes with enhanced reactivity (@jacs.acspublications.org). These rotaxanes were shown to deprotect faster compared to non-interlocked structures due to conformational preorganisation. ๐ CSD Entry XAJJEC: dx.doi.org/10.5517/ccdc... #FeaturedStructureFriday
Jason C. Cole (@theduckmachine.bsky.social) reply parent
Is "The popular peoples' front of Judea" taken?
Jason C. Cole (@theduckmachine.bsky.social) reply parent
It's cool for England. Spanish keeper will have forgotten how to play, cos she's had nothing to do all tournament.
Jason C. Cole (@theduckmachine.bsky.social)
Do we think the English team are watching this while relaxing around the pool? #Euro25
Jason C. Cole (@theduckmachine.bsky.social)
Never liked the phrase "Now would be a good time to score a goal", but now would be a good time to score a goal. #Euro25 #GERvESP (apparently)
Bill Smiley (@neokefka99.bsky.social) reposted
And one final thought: Ozzy going out after giving an emotional final performance that raised a ton of money for charity is more spiritually uplifting and did more genuine good than anything any televangelist and religious grifter who railed against him ever did combined.
Jason C. Cole (@theduckmachine.bsky.social)
They will only be conscious when you ask them a question on a Monday morning and they admit they haven't a clue, because they were out on a bit of a bender on Saturday and only woke up from it 2 hours ago.
Jason C. Cole (@theduckmachine.bsky.social) reply parent
Fun game though.
Jason C. Cole (@theduckmachine.bsky.social) reply parent
Ah. FIFA have got it wrong. Ok. Makes sense.
Jason C. Cole (@theduckmachine.bsky.social)
The other thing about #Euro2025. It's sad that once upon a time womens' football was loads of skill and no diving. Clearly diving has now been coached in.
Jason C. Cole (@theduckmachine.bsky.social)
My son has just pointed out that the BBC abbreviations in football are inconsistent. Germany is GER but Spain is ESP... weird. Surely GERvSPA or DEUvESP ...?! #Euro2025
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
Natural products (NPs) play a crucial role in medicine, inspiring over 50% of the drugs on the market. ๐In this work, the team used an 'arrayED' workflow, that enabled high-throughput screening for crystalline NPs amenable to microcrystal electron diffraction (microED). ๐ ccdc-info.com/3GP4yb2
Derek Lowe (@dereklowe.bsky.social) reposted
Do we have any billionaires whose brains are intact? BTW, Johnson says that he โwelcomes the creative destructionโ in federal research funding. Tells you all you need to know.
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
Are you passionate about #Crystallography or #StructuralScience and have an idea that will help to inspire others? Whether itโs with a video, social media series, game, poster, or a hands-on activity โ we can help you make it happen! ๐ Apply: ccdc-info.com/40NnSwf #ChemSky #ChatChemistry
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
Are you at #ACA2025? Stop by booth 30 to get your name on the #CSDLeaderboard and grab a cookie ๐ช(while they last)! @acastructuralsci.bsky.social #Crystallography
Jason C. Cole (@theduckmachine.bsky.social)
That is honestly the most pathetic appeal by the Indian team. #ENGvIND #cricket
Jason C. Cole (@theduckmachine.bsky.social) reply parent
It also looks like some crude fuzzing algorithm has been applied to some of the blots before copying to me.
Susie Dent (@susiedent.com) reposted
Word of the day is โswullockingโ, from 19th-century East Anglian dialect: sultry, sweltering, and sudiferous (sweat-inducing).
Jason C. Cole (@theduckmachine.bsky.social) reply parent
You wouldn't get given that grace in Cambs Junior Div 2 I can tell you. Only 5 turned up so far? Don't lose the toss or you're bowling.
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
Macrocycles constructed from cyclopentadithiophene, termed sulfur[n]arenes have been reported in @jacs.acspublications.org. The sulfur[5]arene monomers in CSD entry ZUXFEH assemble into dimers by cooperative SโฆS sigma-hole interactions. ๐ dx.doi.org/10.5517/ccdc... #FeaturedStructureFriday
Jason C. Cole (@theduckmachine.bsky.social) reply parent
We know where this ends. 3 6 team divisions. Home and Away games (10 matches) and then you have a promotion relegation 4 way knock out to decide who goes up and who goes down along with a championship decider for 1 vs winner of 2 Vs 3 in division 1. That gives you about 12 games for most teams.
Jason C. Cole (@theduckmachine.bsky.social)
Bluesky needs to make delivery of content more timely. I appreciate this may be a compute challenge, but to get better engagement, posts that capture the moment need delivery in the moment. E.g. I'm only just receiving stuff relating to the football last night 20 hours later.
British Antarctic Survey ๐ง (@bas.ac.uk) reposted
We've had a Very Important Ice delivery! These precious ancient ice core samples from Antarctica are expected to reveal a climate record stretching back more than 1.5 million years ๐คฏ That's further than we've ever looked back before. ๐งต 1/4
Jason C. Cole (@theduckmachine.bsky.social)
Fascinating stuff, and I love the point about A.I. at the end; hard for a large language model to realise that what it's being trained on is wrong.
Jason C. Cole (@theduckmachine.bsky.social)
How have England won that? Shocking penalties from both teams really! #ENGvSWE #Euros2025
Noel O'Boyle (@baoilleach.bsky.social) reposted
Very excited about this!
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
๐ถ Validate your experimental crystal structures using experimentally-derived, peer-reviewed data from the #CSD. ๐ In this case study, the software Mogul was used to investigate the relationship between conformations and macroscopic properties in isoflavones. ๐ ccdc-info.com/3GNQQ88 #Pharma
Jake Wintermute (@synbio1.bsky.social) reposted
Pharma companies need to fire whoever names their drugs "idarucizumab" or whatever and get transfeminine people to do it because this shit is solid gold
Jason C. Cole (@theduckmachine.bsky.social) reply parent
Goddamitol should be the name of whatever they use at Dignitas
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
Don't miss our upcoming webinar to learn about the latest updates in the CSD. ๐ Thursday, 24th July ๐ 16:00 (BST) / 11:00 (EDT) ๐ Register: attendee.gotowebinar.com/register/443... Includes live demonstrations of the changes in Mercury and the CSD Python API. #Crystallography #CompChemSky
Jason C. Cole (@theduckmachine.bsky.social)
So, I thought maybe I might look into taking my son to the 5th test on day 5, but it's sold out. Day 3 tickets were available.. at an advertised price of ยฃ160. Thought I might push the boat out and looked at the actual price for 2 tickets. ยฃ1076. Surrey; you should be ashamed. ๐ #Conmen
Jason C. Cole (@theduckmachine.bsky.social) reply parent
I was wrong, but it's a paddling of ducks www.collinsdictionary.com/word-lists/a...
Jason C. Cole (@theduckmachine.bsky.social) reply parent
Monga claims India have been way better. I think that's frankly quite a one eyed point of view.
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
Join us for the first ever Solid Data Summer School at the University of Birmingham! You will gain hands-on experience in: โ๏ธ Data management. โ๏ธ Analysis techniques. โ๏ธComputational tools tailored to solid-state chemistry. ๐ rsc-solid-data.github.io #CompChemSky
Jason C. Cole (@theduckmachine.bsky.social)
So, West Indies cricket have an unwanted record of the most ducks in a test innings. Unfortunate, but does mean we could think about the collective noun for ducks. There are 2: one, ironically, is "team", the other is "paddle". #cricket #WIvAUS ๐
Jason C. Cole (@theduckmachine.bsky.social)
Heard near Lords. "Sundar! I've got a taxi for a Washington Sundar!" #ENGvIND ๐
Jason C. Cole (@theduckmachine.bsky.social)
Jasprit Bumrah in the #ENGvIND test series. Played 2. Lost 2. Just saying. #cricket ๐
trevorlambert.bsky.social (@trevorlambert.bsky.social) reposted
K'n'ell Connells. S*** a brick, Purplebricks. www.bbc.co.uk/news/article...
Jason C. Cole (@theduckmachine.bsky.social) reply parent
New tagline. "Putting the Con into selling houses"
Dan Liebke (@liebcricket.com) reposted
Like so many people these days, the England batters are utterly baffled about how to deal with the outrageous spin coming out of Washington. #ENGvIND ๐
Jason C. Cole (@theduckmachine.bsky.social)
You can have all the T20 and 50 over cricket you like, but test cricket is King ๐ #ENGvIND ๐
Jason C. Cole (@theduckmachine.bsky.social)
Has someone replaced the pitch overnight?! #bbccricket
Jason C. Cole (@theduckmachine.bsky.social) reply parent
I think a better approach would be to stop teams having the right to challenge it, but get the umpires to just check the ball every 10 overs.
Jason C. Cole (@theduckmachine.bsky.social)
As Italy qualifies for the T20 cricket world cup, I think Italian captain Joe Burns may have to change his name to Giuseppe Bruciare! ๐
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
Chemists at The University of Manchester and The Australian National University have synthesized a dysprosium(iii) complex that displays magnetic hysteresis up to 100K (ccdc-info.com/4nChhOD). ๐CSD Entry BADBUI ccdc-info.com/4lCn8Su #FeaturedStructureFriday
Jason C. Cole (@theduckmachine.bsky.social) reply parent
New members will be added no doubt
Jason C. Cole (@theduckmachine.bsky.social)
You never see Ben Stokes and Vincent Van Gogh in the same room at the same time. ๐
CCDC Cambridge (@ccdc.cam.ac.uk) reposted
The program, FERROSCOPE, searches the CSD using higher symmetry as a proxy for potential molecular #FerroelectricMaterials. โ๏ธ84% of a curated list of 156 known molecular ferroelectrics found. โ An extra 17,000 potentially ferroelectric compounds identified. ๐ doi.org/10.1039/D5CE...
Jason C. Cole (@theduckmachine.bsky.social) reply parent
I think the engagement model is quite different. Because there's no real 'algorithm' one has to work harder to see content on here.
Actual names (@actualnames.bsky.social) reposted
Fufu Fang, 30, said he was "surprised to be stopped at the self-service till" at a Tesco near Cambridge as he attempted to buy his sausage. www.bbc.com/news/uk-engl...
Jason C. Cole (@theduckmachine.bsky.social) reply parent
In other news, UK government has decided that misconduct in office can no longer be protected by NDAs. www.gov.uk/government/n...
Jason C. Cole (@theduckmachine.bsky.social) reply parent
It is sad. It's been killed by spammers. Years ago I'd spend 10 mins taking a look to see if there was anything relevant but the volume of spam in the end just meant our email filters just stopped letting messages through. But perhaps #ChemSky can replace it.
Derek Lowe (@dereklowe.bsky.social) reposted
If you needed yet another great big red flashing warning sign, then talk like this - from a sitting Senator yet - is it.
Jason C. Cole (@theduckmachine.bsky.social)
So you can pay to avoid being subject to a tlegal ruling now? The CMA itself should be looked into, as to whether it's fit for purpose. BBC News - Housebuilders to pay ยฃ100m to avoid legal decision www.bbc.com/news/article...
Jason C. Cole (@theduckmachine.bsky.social) reply parent
Also = I didn't realise that people would start digging into my private affairs. Best to get out before they dig too deep..
Jason C. Cole (@theduckmachine.bsky.social)
By declaring, Wiaan Mulder has denied us the chance of seeing a Brian Lara comeback. ๐
Jason C. Cole (@theduckmachine.bsky.social) reply parent
Lucky captain, excellent player, tedious pundit.
Jason C. Cole (@theduckmachine.bsky.social)
Scary as heck.
Jason C. Cole (@theduckmachine.bsky.social) reply parent
Canute actually gets a bad press! He was demonstrating he had no power over the tide to his flattering courtiers. Can't imagine Farage ever doing that.
Jason C. Cole (@theduckmachine.bsky.social)
Is anyone else finding it sad that the line calls of "fault" and "out" now at #Wimbledon are always the same? I wish they'd change it up. Maybe occasionally throw in a recording of one of those old humorous line calls that sounded like the line judge was desperately holding on for a pee.