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Theo Sonobe

@theosonobe.bsky.social

Raccoon with opinions šŸ—‘ šŸ¦ • #CovidIsAirborne #WearAMask #BringBackMasks • Je parle franƧais aussi šŸ‡«šŸ‡· (& ES šŸ‡ŖšŸ‡ø / DE šŸ‡©šŸ‡Ŗ / ę—„ęœ¬čŖž šŸ‡ÆšŸ‡µ)

created November 13, 2024

9 followers 36 following 38 posts

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Posts

Profile picture Gregg Gonsalves (@gregggonsalves.bsky.social) reposted

So #RFKJr is a liar. He's a charlatan. @kasie.bsky.social catches him here and it's wonderful to watch. We need more of this. Do not give this man any credibility. He's a huckster with famous name and is destroying public health and science in America. Spread the word.

2/9/2025, 10:08:50 PM | 245 71 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

@covidchronicles.bsky.social Oh, rereading my first reply, I said "please relax" — so I basically did say to "calm down" I want to acknowledge that because otherwise it's like I'm gaslighting you (insult to injury there) I apologize for my phrasing šŸ¤

2/9/2025, 10:12:25 PM | 1 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Oh please don’t misunderstand me — I think you have every right to be angry in general lol Things were horrible prior to 2025, and 2025 has brought fresh hell month after month. We need people to wake tf up. Let’s šŸ‘ get šŸ‘ the šŸ‘ revolution šŸ‘ going šŸ‘

2/9/2025, 10:05:27 PM | 1 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

I get you totally. And I appreciate you responding without getting angry. I was hoping my comment wouldn’t spark anything — especially since I respect your advocacy and appreciate your posts šŸ’œ keep up the good fight

2/9/2025, 9:46:04 PM | 1 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

This isn’t a paper granting azelastine (a generic medication…) manufacturers permission to run advertisements claiming it protects against covid And my goodness, please relax. Azelastine has been identified as a candidate for years and years now. I for one am extremely happy to see this study.

2/9/2025, 9:11:44 PM | 5 0 | View on Bluesky | view

Profile picture Eric Topol (@erictopol.bsky.social) reposted

A nasal spray reduced the risk of Covid infections in a double blind, placebo controlled randomized trial jamanetwork.com/journals/jam...

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2/9/2025, 3:16:51 PM | 576 158 | View on Bluesky | view

Profile picture Dr. Lucky Tran (@luckytran.com) reposted

New Mexico has issued a public health order that removes federal restrictions to COVID-19 vaccine access so that pharmacies in New Mexico can vaccinate people of all ages and risk profiles. Every state need to do this!

PUBLIC HEALTH ORDER NEW MEXICO DEPARTMENT OF HEALTH SECRETARY GINA DEBLASSIE AUGUST 29, 2025 Ensuring Availability of COVID-19 Vaccine for the 2025-2026 Season THIS ORDER supersedes any previous order, proclamation, or directives to the extent they are in conflict. This Public Order shall take effect immediately and remain in effect until such time as it automatically expires one year from the date of issuance, or until such time as the New Mexico Department of Health Cabinet Secretary rescinds it.
31/8/2025, 5:04:38 PM | 27228 8386 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Wow. Good on Colorado. Georgia state — please? 🄓 (I don’t think they’re going to do anything close to Colorado here)

31/8/2025, 11:23:05 PM | 0 0 | View on Bluesky | view

Profile picture Dr. Lucky Tran (@luckytran.com) reposted

Many states don’t let you get a COVID vaccine without a prescription as they had existing laws that tied access to official CDC approval. This made sense as a safety measure, but now the CDC has been taken over by antivaxxers, several states are rightfully modifying these laws to reinstate access.

31/8/2025, 8:18:08 PM | 839 176 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

I’m surprised how ā€œin the darkā€ I’ve been relative to the current variant landscape in that, had you asked me before seeing your post, I’d have probably guessed NB.1.8.1 was dominant in the US and that’s totally not the case. Really appreciate the work you do! Now more than ever…

30/8/2025, 8:14:58 PM | 1 0 | View on Bluesky | view

Profile picture Katelyn Jetelina (@kkjetelina.bsky.social) reposted

CDC employees standing up and walking out in light of the mass shootings, firings, and *waves hands in the air* everything else. #USAnotRFK Lets gooooo

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28/8/2025, 6:59:50 PM | 13466 3408 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social)

Wow. Please and thank you.

27/8/2025, 6:50:45 PM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social)

mNEXSPIKE, Moderna's new vaccine (mRNA-1283 instead of mRNA-1273), is based on LP.8.1! Great news! static.modernatx.com/pm/6cef78f8-...

27/8/2025, 5:59:55 PM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Oh. My god. Not a good look for Novavax evangelists…

26/8/2025, 3:57:54 AM | 2 0 | View on Bluesky | view

Profile picture Sean Mullen, Ph.D. (@drseanmullen.bsky.social) reposted reply parent

3/ How do you reconcile teaching brain health while ignoring the virus that harms the brain? By lecturing unmasked in an unfiltered room during a surge? You don’t. You just sweep the evidence under the rug.

25/8/2025, 7:37:47 PM | 104 24 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social)

Welp, it's officially been one year since the 2024-25 COVID vaccine was approved. This year was supposed to be earlier. Things were scheduled a bit earlier. Normally, we might've had the vaccine in arms by now. But no. ā±ļøšŸ™„ www.fda.gov/news-events/...

22/8/2025, 9:16:30 PM | 0 0 | View on Bluesky | view

Profile picture M A Osborne (@maosbot.bsky.social) reposted

I can’t square the following: 1. covid, and many other respiratory viruses, are (still) out there causing long-term damage to multiple organ systems 2. well-fitted respirators, by the very laws of physics, protect both you and those around you 3. no-one is masking

16/8/2025, 12:46:41 PM | 245 60 | View on Bluesky | view

Profile picture Chise (@sailorrooscout.bsky.social) reposted

WELL NOW, would you look at that? A massive, 24-YEAR-LONG study of MORE THAN 1.2 MILLION people in Denmark found NO LINK between aluminum in childhood vaccines and autism, asthma, OR chronic disorders. Aluminum is an ADJUVANT. It ENHANCES your immune response to a vaccine. That’s it.

16/8/2025, 4:30:46 PM | 5367 1762 | View on Bluesky | view

Profile picture Pete Buttigieg (@petebuttigieg.bsky.social) reposted

No, JD, belonging in America does not depend on how many generations of your family have lived here. The values of this country matter - deeply - to who we are and what it means to be American.

12/8/2025, 1:31:41 AM | 18983 5050 | View on Bluesky | view

Profile picture Eric Topol (@erictopol.bsky.social) reposted

We're still seeing great promise of COVID nasal vaccines with various vectors, preventing infection and transmission, but the HHS cancellation of US support will very likely derail the progress that has been made www.pnas.org/doi/10.1073/... www.science.org/doi/10.1126/...

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6/8/2025, 9:32:01 PM | 420 182 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

How does this look compared to, say, the early days of BA.2.86? (As in, how does this GA genome compare to saltations we’ve seen in omicron offshoots?) Thank you very much in advance — I really appreciate all the work you do btw!

27/7/2025, 8:31:51 PM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Are you able to say which contemporary variant has the closest spike to GA-1? (Guesses are fine too)

27/7/2025, 5:14:26 AM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Fuck.

25/7/2025, 9:00:36 PM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Semaglutide is a peptide So no, peptides are not all pseudoscience…

14/7/2025, 3:20:50 AM | 0 0 | View on Bluesky | view

Profile picture Chise (@sailorrooscout.bsky.social) reposted

There are currently more kids in Texas with measles than there are transgender collegiate athletes in all of America. Guess which one they want you to focus on.

12/7/2025, 4:00:12 PM | 6710 2388 | View on Bluesky | view

Profile picture Dr. Lucky Tran (@luckytran.com) reposted

The Big Death Bill has passed. The GOP willingly chose to kick millions off health insurance, close hundreds of hospitals, nursing homes, & reproductive health clinics, leave millions of families without enough food & kill thousands of people. This is the biggest assault on health in recent history.

3/7/2025, 6:41:06 PM | 527 190 | View on Bluesky | view

Profile picture Dr. Lucky Tran (@luckytran.com) reposted

One of the most tragic things is that so many people that will be harmed by the Big Death Bill will be completely unaware about what just happened until it’s way too late and they can’t see a doctor or get a hospital bed in their time of need.

3/7/2025, 7:18:24 PM | 677 165 | View on Bluesky | view

Profile picture Dr. Lucky Tran (@luckytran.com) reposted

Wow. Lenacapavir, a twice-yearly shot that prevents HIV spread was just approved by the FDA. The problem? Due to government cuts to Medicaid, PEPFAR, and Global Fund, it's unlikely this game-changing drug will reach the many people who need it most in the US and globally.

18/6/2025, 6:53:07 PM | 1570 627 | View on Bluesky | view

Profile picture Dr. Lucky Tran (@luckytran.com) reposted

Masks are under serious threat at being banned widely due to politicization. This would be a public health disaster. If you are only wearing a mask at protests, please consider also wearing them elsewhere. The more people mask, the more we normalize masks and protect them against bans.

15/6/2025, 3:20:50 PM | 3281 1459 | View on Bluesky | view

Profile picture Dr. Lucky Tran (@luckytran.com) reposted

People are being arrested for wearing a medical mask in Savannah, Georgia #NoKings

14/6/2025, 7:12:38 PM | 3297 1721 | View on Bluesky | view

Profile picture Edward Nirenberg (@enirenberg.bsky.social) reposted

So much this coloradonewsline.com/2025/06/13/t...

13/6/2025, 10:52:06 PM | 82 35 | View on Bluesky | view

Profile picture Edward Nirenberg (@enirenberg.bsky.social) reposted

Friends- it is 2025. Can we stop with the term "vaccine skeptic" to describe people openly hostile to vaccines and whose views are not based in evidence? That is not skepticism. That is denialism.

12/6/2025, 8:10:59 PM | 349 84 | View on Bluesky | view

Profile picture Lizzie O'Leary (@lizzieohreally.bsky.social) reposted

You do not have to say ā€œpro vaccine groups.ā€ You can say the vast majority of doctors and scientists and the American Medical Association.

11/6/2025, 11:24:19 PM | 13132 2526 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social)

Invivyd @invivyd.bsky.social *proudly* lobbied the FDA to require new placebo-controlled trials for any COVID vaccine updates investors.invivyd.com/news-release... Extremely disappointed. I had a lot of hope in this company and their product. Shame on them. @enirenberg.bsky.social

11/6/2025, 6:54:44 PM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social)

They *knew* LP.8.1 had reached its peak and *knew* NB.1.8.1 was going to rise It was obvious to everyone And yet we still chose LP.8.1 instead of NB.1.8.1 or even XFG for the fall vaccine (That we will hopefully still have…) Ugh. @enirenberg.bsky.social

11/6/2025, 6:44:24 PM | 0 0 | View on Bluesky | view

Profile picture Dr. Lucky Tran (@luckytran.com) reposted

"We are speaking on behalf of hundreds of NIH staff who are standing up together to say: WE DISSENT. I am so scared about doing this but I am trying to be brave for my kids because it's only gonna get harder to speak up." Thank you to Dr. Jenna Norton and NIH scientists for your courage!

9/6/2025, 5:25:34 PM | 1165 408 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Ohh ok. Gosh you've become proficient in this stuff. This "different spike" — did BA.2.86 present with a similar degree of difference or was it more run-of-the-mill and BA.3.2 is not only a saltation but a saltation with spike 'features' out of the ordinary (I hope that made any sense...)

6/6/2025, 5:58:40 PM | 1 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

2/2 …to be decently neutralizable / not too fit, but quickly caught up and grabbed the new mutations to swing itself to the top of the growth charts? (&, for example, the positive results for, say, Evushields component that neutralizes now could easily vanish(?)) Any take of yours, I’d appreciate

6/6/2025, 4:21:42 PM | 1 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

1/2 thanks for the write up, @ryanhisner.bsky.social Ryan! Given this bit of new info, any predictions / thoughts on the potential expansion of this saltation? Also, do you think preliminaries on neutralization might follow the same pattern we saw with BA.2.86 where the spike seemed…

6/6/2025, 4:21:42 PM | 2 0 | View on Bluesky | view

Profile picture Gregg Gonsalves (@gregggonsalves.bsky.social) reposted

Just watch Margaret Brennan eviscerate Marty Makary in this interview. He is evasive, makes misleading statements, outright lies and contradicts himself, while chanting RCT-RCT-RCT as some talisman to excuse what he has done to make Americans less safe from COVID-19. www.youtube.com/watch?v=WGH2...

3/6/2025, 8:34:17 PM | 108 32 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Fascinating findings! Is there a comparison to other variants (older than KP/JN) in terms of inflammatory response differences? Or is this mutation unique and the increased inflammation something we haven’t had in prior variants?

31/5/2025, 9:25:22 PM | 1 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Would really like to see @novavax.bsky.social update to LP.8.1 for this fall šŸ¤ž #novavax

venn diagram comparing JN.1 to LP.8.1
23/5/2025, 8:14:36 PM | 1 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Forgot to add the link: cov-spectrum.org/explore/Unit...

23/5/2025, 8:04:48 PM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Quick view of the mutational differences between KP.2 and LP.8.1 for anyone interested

A venn diagram showing the shared and additional mutations the LP.8.1 strain has compared to the KP.2 strain
23/5/2025, 8:04:00 PM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social)

Looks like the FDA officially endorsed LP.8.1 @enirenberg.bsky.social www.fda.gov/vaccines-blo... #covid #wearAMaskPlease

23/5/2025, 8:02:16 PM | 1 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

lol recommending a monovalent, JN.1-lineage As opposed to an XBB šŸ‘½ The FDA meeting notes even looked like they’d only been slightly modified from last year’s 🫠

22/5/2025, 7:49:08 PM | 0 0 | View on Bluesky | view

Profile picture Edward Nirenberg (@enirenberg.bsky.social) reposted

I used to listen to the public comment period at VRBPAC and ACIP meetings but the frequency with which they attract bad-faith actors or otherwise delusional people has grown wearisome.

22/5/2025, 5:26:57 PM | 23 2 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social)

Opened the livestream for the FDA 2025-2026 COVID strain meeting and had to close out after a few seconds for my mental health / general sanity Just gotta wait for the verdict. My anxious / frustrated viewing wont change the outcome. šŸ™ LP.8.1 please, thanks šŸ™ (also, el oh el if NVX is JN.1)

22/5/2025, 7:08:51 PM | 4 1 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

You know what, you’re definitely right. I think it’s harder to tell myself that and believe it vs hearing it directly from a trusted authority on the subject (you) Maybe I should put deference on the studies that compare the variants? Idk. Industry sponsoring usually adds to my lack of finality

22/5/2025, 6:58:09 PM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Obviously, I wish I could pick from a dropdown menu and DIY it lol Data from pan studies showed how it’s probably best to vax with distant versions — to get naive B cells and ideally breadth as a result Idk. I’m way too deep in this stuff. I wish I could get my nasal vaccine and move on

22/5/2025, 6:55:09 PM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

I agree. However, I usually find myself going back to the ā€œwell, if there’s such little difference, then how did these variants manage to dominate to the degree they didā€ Obv more than S matters, but tbh it just makes me think those extra few mutations might really matter going forward

22/5/2025, 6:52:30 PM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Blah. Meant to say, I really hope for LP.8.1 Was hoping for more options (like NB or XFG), but I get why this year, the risk:benefit ratio of being cutting edge didn’t seem worth it to the manufacturers It’s weird to go from ā€œman I hope they select NB/XFG and not LPā€ to ā€œpls update from KP.2ā€

22/5/2025, 6:47:39 PM | 1 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

The 3 company’s presentations remind me of last years — where I was left feeling like Pfizer’s data was the best (collected, presented, and summary efficacy) And freaking praying they’d choose KP.2. Was so annoyed initially. V glad they ended up doing the right thing and allowing KP.2

22/5/2025, 6:45:49 PM | 1 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Wow. Maybe they should’ve found a different abbreviation than ND for these lool I obviously skimmed the 3 presentations so I didn’t closely examine, but I immediately thought ā€œnot detectedā€ — which made all the data seem strange. Appreciate you covering this!

22/5/2025, 6:43:06 PM | 0 0 | View on Bluesky | view

Profile picture Edward Nirenberg (@enirenberg.bsky.social) reposted reply parent

It is astonishing that they are demanding a placebo control here. This is brazenly unethical. There is no equipoise about whether or not COVID-19 vaccines work. You cannot give people saline to evaluate a strain update (and while not explicitly stated they seem to be suggesting that strain...

20/5/2025, 4:17:54 PM | 220 42 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Just in time for the strain selection meeting..! Hopefully they see this (…and hopefully we still get an updated Covid vaccine this fall..)

19/5/2025, 4:54:47 AM | 4 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

@ryanhisner.bsky.social The antigenic distance shown in the map makes BA.3.2, potentially, a great candidate for a (hypothetical) booster if it grew in dominance (Would allow for recruitment of naive B-cells instead of pure recall) I wonder if we’ll even get an updated booster for this fall… šŸ˜•

5/5/2025, 4:48:21 AM | 1 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Wow — that’s a Covid cautious dream come true šŸ˜ I know you’ve traveled a good bit the past few years—how does SF compare to other cities in this regard? Are there other cities you’d say have (relatively) good aerosol mitigations? (I know, big generalizations, but still)

5/5/2025, 4:40:58 AM | 0 0 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

@kprather.bsky.social How can it be so low?? Honest question! (Is it because of the local weather making it easier to bring in outdoor air?) (Also thank you so much for all the work you do šŸ’›)

4/5/2025, 10:53:22 PM | 2 0 | View on Bluesky | view

Profile picture Dr. Lucky Tran (@luckytran.com) reposted

The COVID vaccines have been taken by billions of people, saved millions of lives, and are some of the most rigorously tested medical products in history. Someone who has zero experience in vaccine development should not be influencing the approval process. This will kill people.

Kennedy Issues Demands for Vaccine Approvals That Could Affect Fall Covid Boosters The plans amount to an extraordinary flex of Robert F. Kennedy Jr.’s power as health secretary to make decisions ordinarily left to career scientists at the Food and Drug Administration.
1/5/2025, 11:04:57 PM | 2876 875 | View on Bluesky | view

Profile picture Dr. Lucky Tran (@luckytran.com) reposted

Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.

28/4/2025, 5:20:46 PM | 5114 2422 | View on Bluesky | view

Profile picture Carl T. Bergstrom (@carlbergstrom.com) reposted

Again, they're trying to take away our vaccines. From the head of the FDA, a gross misrepresentation of the annual process of updating a proven vaccine to target new disease strains. His plan would make it impossible to get seasonal flu and Covid shots, and of course he knows this.

To be clear, this is a new product that Novavax is trying to introduce to the market with a study of a different product from 2021. New products require new clinical studies. Under this administration, we are prioritizing the Gold Standard of Science--not what saves pharma companies
28/4/2025, 9:37:10 PM | 3276 1391 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

I’ve been listening to the audiobook and smiled a ton when you were mentioned in it!! Truly appreciate the work you do!

8/3/2025, 2:08:11 AM | 2 0 | View on Bluesky | view

Profile picture Kelly (@broadwaybabyto.bsky.social) reposted

The news is awful right now. We’re all exhausted Please don’t underestimate the effect that this cascade of overwhelmingly awfulness has on your nervous system. Especially if you’re chronically ill. Take breaks. We will be here when you return. Give yourself grace. It’s a marathon, not a sprint.

21/1/2025, 8:42:34 AM | 1448 334 | View on Bluesky | view

Profile picture Theo Sonobe (@theosonobe.bsky.social) reply parent

Wish I could opt to take my chances and receive this. So desperate for a nasal vaccine

8/12/2024, 10:37:33 PM | 1 0 | View on Bluesky | view